Usnarska-Zubkiewicz L, Czarnecka M, Włodarczyk S, Nowak E
Katedra i Klinika Hematologii i Chorób Rozrostowych Krwi, Akademia Medyczna we Wrocławiu.
Pol Arch Med Wewn. 1997 Mar;97(3):253-9.
7 out of 154 patients with multiple myeloma (MM) with concomitant rheumatoid arthritis (RA) (5 persons) and Bechterev disease (BD) (2 persons) have been presented. There were 5 women and 2 men at age from 52 to 67 years. Four of them had joint's disease for 4, 5, 24 and 25 years prior to MM, and in the next there MM was diagnosed simultaneously with RA. Two patients are still living (50 and 55 months from the diagnosis of MM), the mean survival time of the five already dead was 34.5 months, and did not differ from the survival of patients with MM alone. The contribution of interleukin-6 (Il-6) and adhesion molecules ICAM-1, VCAM-1, CD44 in pathogenesis of both diseases are discussed.
本文报告了154例多发性骨髓瘤（MM）患者中，同时合并类风湿关节炎（RA）（5例）和贝赫切特病（BD）（2例）的情况。患者年龄在52至67岁之间，其中女性5例，男性2例。4例患者在患MM之前，关节疾病已分别存在4年、5年、24年和25年，另外2例患者MM与RA同时诊断。2例患者仍存活（自MM诊断起已分别存活50个月和55个月），5例已故患者的平均生存时间为34.5个月，与单纯MM患者的生存率无差异。本文还讨论了白细胞介素-6（Il-6）以及黏附分子ICAM-1、VCAM-1、CD44在这两种疾病发病机制中的作用。
