Schött D
Innere Abteilung des Kreiskrankenhauses Siegen, Akademisches Lehrkrankenhaus der Universität, Marburg.
Pneumologie. 1997 Jul;51(7):634-9.
After the stabilization of the obstructive airways disease 14 patients performed 4 times exercise-tests of 6 minutes at a bicycle during one week. The basic values of the lung function showed with FEV1 of 66%, Rt of 5,74 hPa/l/s and IGV of 155% a strong disturbance of the mechanical features of the lung. At the mean during the exercise tests the PO2a remained with 69 Torr constant. PC2a increases at the same time for 3 Torr. After the exercise test a significant increase of PO2a of 11.4 Torr takes place. At the individual patients there was a great variability of the results between the different tests. Only three patients showed always a decrease of PO2a-values. The reason for this variability is the ventilation/perfusion inhomogeneity, which changes between the investigations. There are significant multilinear correlations between the FEV1%- as the IGV%-values and PO2a for the values at rest, during exercise as 5 min after the end of exercise. The exercise tests show at the PO(2a)-values the variability of the ventilation/perfusion inhomogeneity which dominates the bloodgas values. The important increase of the PO2a after the exercise test even at this patients can be of importance. The duration of this effect after multiple loads and the dependence of the workload should be investigated.
在阻塞性气道疾病病情稳定后,14名患者在一周内于自行车上进行了4次6分钟的运动测试。肺功能的基础值显示,第一秒用力呼气容积(FEV1)为66%,气道阻力(Rt)为5.74 hPa/l/s,吸气储备容积(IGV)为155%,提示肺部力学特征存在严重紊乱。在运动测试期间,动脉血氧分压(PO2a)平均维持在69 Torr不变。同时,动脉二氧化碳分压(PC2a)升高了3 Torr。运动测试后,PO2a显著升高11.4 Torr。在个体患者中,不同测试结果存在很大差异。只有三名患者的PO2a值始终下降。这种差异的原因是通气/灌注不均匀性,其在不同检查之间会发生变化。在静息状态、运动期间以及运动结束后5分钟时,FEV1%和IGV%值与PO2a之间存在显著的多元线性相关性。运动测试显示,PO(2a)值存在通气/灌注不均匀性的差异,这种差异主导了血气值。即使在这些患者中,运动测试后PO2a的重要升高也可能具有重要意义。应研究多次负荷后这种效应的持续时间以及工作量的依赖性。