Feldman R, Burda P R, Glińska-Serwin M, Kotlarska M, Szajewski J
II Oddziału Chorób Wewnetrznych ze Stołecznym Ośrodkiem Ostrych Zatruć, Szpital Praski w Warszawie.
Przegl Lek. 1997;54(6):410-5.
Acute carbamazepine (CBZ) poisoning occurs recently quite often. Symptomatology of poisoning is variable but usually various degrees of consciousness impairment prevail. 77 patients (36 women and 41 man, mean age 31.5) were hospitalized last two years in this Centre. Clinical condition was evaluated in a regular descriptive way, classifying the degree of coma according to the Matthew scale but also by calculating the scores according to APACHE II and TOXSCORE. Serum CBZ was measured. A slight falling trend was found of the relation of the serum CBZ in the range 6-37.8 micrograms/ml (38 micrograms/ml = median) to APACHE II score and the TOXSCORE and slight rising trend of the relation of the serum CBZ to the degree of coma. The significance of this trend rose essentially at the serum CBZ levels of more than the median 38 micrograms/ml. The causes of the non significant correlation of serum CBZ (in particularly range) to the clinical condition is discussed. The individuals factors of the patient and possible effect of other, unknown drugs taken together with CBZ seem to play a minor role at the concentrations above 38 micrograms/ml. A very precise correlation has been found at the serum concentrations exceeding 40 micrograms/ml.
急性卡马西平（CBZ）中毒近来较为常见。中毒症状多样，但通常以不同程度的意识障碍为主。在过去两年中，该中心收治了77例患者（36名女性和41名男性，平均年龄31.5岁）。以常规描述方式评估临床状况，根据马修量表对昏迷程度进行分类，同时也根据急性生理与慢性健康状况评分系统II（APACHE II）和中毒严重程度评分（TOXSCORE）计算得分。检测血清卡马西平水平。发现血清卡马西平水平在6 - 37.8微克/毫升（38微克/毫升为中位数）范围内与APACHE II评分及TOXSCORE之间呈轻微下降趋势，而血清卡马西平水平与昏迷程度之间呈轻微上升趋势。这种趋势在血清卡马西平水平超过中位数38微克/毫升时基本增强。文中讨论了血清卡马西平（特别是在该范围内）与临床状况无显著相关性的原因。在浓度高于38微克/毫升时，患者的个体因素以及与卡马西平一起服用的其他未知药物的可能影响似乎起次要作用。在血清浓度超过40微克/毫升时发现了非常精确的相关性。
