Derizhanova I S, Salmn A Kh
Arkh Patol. 1997 Jul-Aug;59(4):25-8.
The authors studied endocrine apparatus of the mucous membrane of 53 stomachs in various forms of carcinoma. Silver impregnation and electron microscopy were used as well as routine histology and histochemistry. All the tumors were divided into endocrine-cell and non-endocrine-cell tumors (ET and NET). Cells of the diffuse endocrine system take an important part in the development of the background and pretumorous processes in the stomach mucous membrane. Endocrinocyte hyperplasia, degree I and II, of the mucous membrane of the antrum and enterolysation foci was the background for all NET. Endocrinocyte hyperplasia was more pronounced (degree II and III) in ET and spread to the fundal glands being combined with endocrinocyte dysplasia and metaplasia. These changes are assessed as precancerous for tumors with high content of endocrinocytes.
作者研究了53例不同类型胃癌患者胃黏膜的内分泌器官。采用了银浸染法、电子显微镜技术以及常规组织学和组织化学方法。所有肿瘤分为内分泌细胞肿瘤和非内分泌细胞肿瘤（ET和NET）。弥漫性内分泌系统的细胞在胃黏膜背景和癌前病变过程的发展中起重要作用。胃窦黏膜和肠化生灶的I级和II级内分泌细胞增生是所有NET的背景。ET中的内分泌细胞增生更明显（II级和III级），并扩散至胃底腺，伴有内分泌细胞发育异常和化生。对于内分泌细胞含量高的肿瘤，这些变化被评估为癌前病变。
