Lima L, Urbina M, Drujan B
Instituto Venezolano de Investigaciones Científicas, Centro de Biofísica y Bioquímica, Caracas, Venezuela.
Acta Cient Venez. 1995;46(3):161-5.
The paraplegic syndrome of bovines is a condition characterized by impairment of locomotion, hypoalgesia and finally death within 72 h. The pathogenesis of the syndrome has not been established. In the present work we determined the levels of monoamines and their metabolites in cerebro-spinal fluid and spinal cord of affected animals in order to investigate the functional state of these neurotransmitters. The content of the main metabolite of serotonin, 5-hydroxyindoleacetic acid, was elevated in the cerebro-spinal fluid and in the gray matter of the spinal cord of paraplegic bovines. Serotonin content in the spinal cord did not differ with respect to control animals, but was decreased in the cerebro-spinal fluid of affected animals. Modifications in the noradrenergic system were also observed, but were less consistent, for which reason further studies are needed. These observations indicate an increase in the turnover rate of serotonin in the paraplegic syndrome. The meaning of the described alterations is unknown at the moment.
牛的截瘫综合征是一种以运动障碍、痛觉减退并最终在72小时内死亡为特征的病症。该综合征的发病机制尚未明确。在本研究中，我们测定了患病动物脑脊液和脊髓中单胺及其代谢产物的水平，以研究这些神经递质的功能状态。截瘫牛的脑脊液和脊髓灰质中，血清素的主要代谢产物5-羟吲哚乙酸含量升高。脊髓中的血清素含量与对照动物相比无差异，但患病动物脑脊液中的血清素含量降低。同时也观察到了去甲肾上腺素能系统的变化，但不太一致，因此需要进一步研究。这些观察结果表明截瘫综合征中血清素的周转率增加。目前尚不清楚上述改变的意义。
