人体脊髓中的血清素和去甲肾上腺素。

Serotonin and norepinephrine in the spinal cord of man.

作者信息

Lacković Z, Jakupcević M, Bunarević A, Damjanov I, Relja M, Kostović I

机构信息

Department of Pharmacology, Medical School of Zagreb, Yugoslavia.

出版信息

Brain Res. 1988 Mar 8;443(1-2):199-203. doi: 10.1016/0006-8993(88)91613-7.

DOI:10.1016/0006-8993(88)91613-7

PMID:2451990

Abstract

The content of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) was analysed in 71 human spinal cords obtained post-mortem. The highest content of 5-HT, 5-HIAA and NE was found in the lumbar enlargement of the spinal cord. 5-HT and 5-HIAA content increased from fetal to adult spinal cord whereas the content of NE decreased. Characteristic segmental distribution of measured monoamines was present in adult spinal cord only. In two patients spinal cord lesion led to the reduction in spinal cord content of 5-HT, 5-HIAA and NE and loss of characteristic segmental distribution of these substances. These results are in general agreement with observations on spinal cord of different animal species.

摘要

对71例死后获取的人体脊髓组织进行了5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）和去甲肾上腺素（NE）含量的分析。发现脊髓腰膨大处的5-HT、5-HIAA和NE含量最高。从胎儿脊髓到成人脊髓，5-HT和5-HIAA的含量增加，而NE的含量降低。仅在成人脊髓中存在所测单胺类物质的特征性节段分布。两名患者的脊髓损伤导致脊髓中5-HT、5-HIAA和NE含量降低，且这些物质的特征性节段分布消失。这些结果总体上与对不同动物物种脊髓的观察结果一致。