Tsambaos D, Georgiou S, Monastirli A, Sakkis T, Sagriotis A, Goerz G
Department of Dermatology, University of Patras, Greece.
J Urol. 1997 Nov;158(5):1810-2. doi: 10.1016/s0022-5347(01)64136-3.
The aim of our study was to evaluate the efficacy and safety of oral isotretinoin in the treatment of condylomata acuminata.
A total of 56 male patients with a history of condylomata acuminata refractory to at least 1 standard therapeutic regimen was treated orally with isotretinoin (1 mg./kg. daily) during a 3-month period.
At the end of treatment 21 of the 53 evaluated patients (39.6%) had complete response, 7 (13.2%) had partial response and 25 (47.1%) had no response. A statistically significant inverse relationship was found between age and area of treated lesions and response to medication. Two complete responders (9.5%) revealed recurrence during the 1-year followup.
Oral isotretinoin may be regarded as an effective, fairly well tolerated and noninvasive alternative form of therapy for immature and small condylomata acuminata.
