Treatment of condylomata acuminata with oral isotretinoin.

PURPOSE

The aim of our study was to evaluate the efficacy and safety of oral isotretinoin in the treatment of condylomata acuminata.

MATERIALS AND METHODS

A total of 56 male patients with a history of condylomata acuminata refractory to at least 1 standard therapeutic regimen was treated orally with isotretinoin (1 mg./kg. daily) during a 3-month period.

RESULTS

At the end of treatment 21 of the 53 evaluated patients (39.6%) had complete response, 7 (13.2%) had partial response and 25 (47.1%) had no response. A statistically significant inverse relationship was found between age and area of treated lesions and response to medication. Two complete responders (9.5%) revealed recurrence during the 1-year followup.

CONCLUSIONS

Oral isotretinoin may be regarded as an effective, fairly well tolerated and noninvasive alternative form of therapy for immature and small condylomata acuminata.