破伤风神经毒素重链受体结合片段的结构
Structure of the receptor binding fragment HC of tetanus neurotoxin.
作者信息
Umland T C, Wingert L M, Swaminathan S, Furey W F, Schmidt J J, Sax M
出版信息
Nat Struct Biol. 1997 Oct;4(10):788-92. doi: 10.1038/nsb1097-788.
PMID:9334741
Abstract
The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin.
摘要
破伤风神经毒素受体结合片段Hc的2.7埃结构揭示了一个果冻卷结构域和一个β-三叶结构域。Hc保留了全毒素独特的转运特性，并且能够引发针对全长全毒素的保护性免疫反应。
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