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德国牧羊犬遗传性多灶性肾囊腺癌的计算机断层扫描

Computed tomography of hereditary multifocal renal cystadenocarcinomas in German shepherd dogs.

作者信息

Moe L, Lium B

机构信息

Department of Small Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo, Norway.

出版信息

Vet Radiol Ultrasound. 1997 Sep-Oct;38(5):335-43. doi: 10.1111/j.1740-8261.1997.tb02094.x.

DOI:10.1111/j.1740-8261.1997.tb02094.x
PMID:9335089
Abstract

The purpose of the study was to characterize the renal lesions of hereditary renal cystadenocarcinomas in the German shepherd dog using computed tomography (CT). Fourteen dogs with renal cystadenocarcinomas and nodular dermatofibrosis, and two unaffected dogs were studied. There were nine dogs with spontaneous disease and seven dogs from a test mating. The characteristic renal CT findings of renal cystadenocarcinomas were bilateral multiple cysts and tumor masses of various sizes. The earliest changes were detected between 4 and 5 years of age and the smallest cysts measured 2-3 mm in diameter. Abdominal CT examination gives a wide field view and excellent anatomic images of the kidneys. It is easy to differentiate between cysts and solid tumors. CT examination is useful for the early detection of renal cystadenocarcinomas and for screening suspected carrier dogs before breeding.

摘要

本研究的目的是利用计算机断层扫描(CT)对德国牧羊犬遗传性肾囊腺癌的肾脏病变进行特征描述。对14只患有肾囊腺癌和结节性皮肤纤维瘤的犬以及2只未受影响的犬进行了研究。其中9只为自发性疾病犬,7只为试验性配种犬。肾囊腺癌的特征性肾脏CT表现为双侧多发性囊肿和大小各异的肿瘤块。最早的变化在4至5岁时被检测到,最小的囊肿直径为2 - 3毫米。腹部CT检查能提供广阔视野和出色的肾脏解剖图像。很容易区分囊肿和实体瘤。CT检查对于肾囊腺癌的早期检测以及在繁殖前筛查疑似携带犬很有用。

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Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis.肾囊腺癌和结节性皮肤纤维瘤病犬早期肾囊性病变中FLCN基因座杂合性缺失
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引用本文的文献

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Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma.犬原发性肾肿瘤(包括肾细胞瘤、淋巴瘤和血管肉瘤)的增强 CT 表现。
PLoS One. 2019 Nov 22;14(11):e0225211. doi: 10.1371/journal.pone.0225211. eCollection 2019.
2
Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis.肾囊腺癌和结节性皮肤纤维瘤病犬早期肾囊性病变中FLCN基因座杂合性缺失
Mamm Genome. 2009 May;20(5):315-20. doi: 10.1007/s00335-009-9183-8. Epub 2009 Apr 23.
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Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.
犬自然发生的遗传性肾癌综合征的基因定位
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4132-7. doi: 10.1073/pnas.070053397.