Buemi M, Allegra A, Aloisi C, Corica F, Alonci A, Ruello A, Montalto G, Frisina N
Department of Internal Medicine, University of Messina, Italy.
Hypertension. 1997 Oct;30(4):845-7. doi: 10.1161/01.hyp.30.4.845.
In patients with essential hypertension, elevated soluble E-selectin (sE-selectin) levels may indicate endothelial cell injury or activation. We therefore sought to ascertain whether arterial blood pressure increased by the cold pressor test can modify serum concentrations of sE-selectin and other soluble forms of adhesion molecules, such as soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), or the expression of any adhesion molecules in circulating monocytes and lymphocytes. Our findings show that levels of sE-selectin, sVCAM-1, and sICAM-1 are higher in patients with essential hypertension than in normotensive subjects (sICAM-1, 380 +/- 52 versus 262 +/- 96 ng/mL, P<.05; sVCAM-1, 720 +/- 52 versus 625 +/- 38 ng/mL, P<.05; and sE-selectin, 75 +/- 21 versus 61 +/- 22 ng/mL, P<.05). Furthermore, in normotensive and hypertensive patients, the cold pressor test caused an increase in serum concentrations of sICAM-1, sVCAM-1, and sE-selectin, but it did not cause changes in the expression of adhesion molecules in circulating monocytes and lymphocytes. High arterial blood pressure may therefore increase the production of serum adhesion molecules, probably through endothelial activation.
在原发性高血压患者中，可溶性E选择素（sE选择素）水平升高可能表明内皮细胞损伤或激活。因此，我们试图确定冷加压试验引起的动脉血压升高是否会改变sE选择素以及其他可溶性黏附分子形式（如可溶性细胞间黏附分子-1[sICAM-1]和可溶性血管细胞黏附分子-1[sVCAM-1]）的血清浓度，或循环单核细胞和淋巴细胞中任何黏附分子的表达。我们的研究结果表明，原发性高血压患者的sE选择素、sVCAM-1和sICAM-1水平高于血压正常的受试者（sICAM-1，380±52对262±96 ng/mL，P<0.05；sVCAM-1，720±52对625±38 ng/mL，P<0.05；sE选择素，75±21对61±22 ng/mL，P<0.05）。此外，在血压正常和高血压患者中，冷加压试验导致sICAM-1、sVCAM-1和sE选择素的血清浓度升高，但未引起循环单核细胞和淋巴细胞中黏附分子表达的变化。因此，高动脉血压可能通过内皮激活增加血清黏附分子的产生。
