Kasza Márta, Meleg J, Vardai J, Nagy B, Szalai E, Damjanovich J, Csutak A, Ujhelyi B, Nagy V
Medical Centre, Hungarian Defence Forces, 1134, Budapest, Róbert Károly krt. 44, Hungary.
Jósa András Hospital, Nyíregyháza, Hungary.
Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):25-30. doi: 10.1007/s00417-016-3411-1. Epub 2016 Jul 4.
Diabetic retinopathy is one of the leading causes of blindness. There are several risk factors, such as the duration of diabetes or glycemic control of the patient; however, several biochemical factors also alter the process. Our aim was to investigate the role of soluble E-selectin in the formation of diabetic retinopathy.
Fifty-seven patients (37 female and 20 male, aged 61.71 ± 12.31 years) and 14 healthy control subjects (ten female and four male, aged 63.06 ± 10.46 years) were enrolled in the study. We measured the soluble E-selectin level in the plasma of patients by ELISA. All patients underwent careful ophthalmological examination, including ophthalmoscopy and color fundus photography, while diabetic retinopathy grading was performed in line with the 2012 classification of the American Academy of Ophthalmology (AAO).
The soluble E-selectin level was significantly higher in patients with diabetes compared to controls (32.95 ng/ml vs. 26.55 ng/ml, p = 0.03). Dividing patients into groups by the presence of retinopathy, the E-selectin level was also significantly higher in the retinopathy group (p < 0.05). When we examined diabetic patients by the severity of retinopathy (groups A, B, and C, by the guidelines of the AAO), however, we did not find any significant difference in soluble E-selectin levels, although it tended to be higher in group B.
An elevated E-selectin level can play a role in the development of diabetic retinopathy, but it does not seem to alter disease severity. However, glycemic control and the reduction of cardiovascular risk factors may also alter the level of E-selectin that might play a role in the prevention of diabetic retinopathy.
糖尿病视网膜病变是导致失明的主要原因之一。存在多种风险因素，如糖尿病病程或患者的血糖控制情况；然而，一些生化因素也会改变这一进程。我们的目的是研究可溶性E选择素在糖尿病视网膜病变形成中的作用。
本研究纳入了57例患者（37例女性和20例男性，年龄61.71±12.31岁）和14名健康对照者（10例女性和4例男性，年龄63.06±10.46岁）。我们通过酶联免疫吸附测定法（ELISA）测量患者血浆中的可溶性E选择素水平。所有患者均接受了仔细的眼科检查，包括检眼镜检查和彩色眼底摄影，同时根据美国眼科学会（AAO）2012年的分类标准进行糖尿病视网膜病变分级。
糖尿病患者的可溶性E选择素水平显著高于对照组（32.95纳克/毫升对26.55纳克/毫升，p = 0.03）。按是否存在视网膜病变将患者分组，视网膜病变组的E选择素水平也显著更高（p < 0.05）。然而，当我们根据视网膜病变的严重程度（按照AAO的指南分为A、B和C组）对糖尿病患者进行检查时，尽管B组的可溶性E选择素水平有升高趋势，但我们并未发现其水平有任何显著差异。
E选择素水平升高可能在糖尿病视网膜病变的发展中起作用，但似乎不会改变疾病的严重程度。然而，血糖控制和心血管危险因素的降低也可能改变E选择素的水平，这可能在预防糖尿病视网膜病变中发挥作用。
