在鹿特丹研究中，对CRTM基因和CRTL1基因与影像学确诊骨关节炎之间关联的调查。
Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study.
作者信息
Meulenbelt I, Bijkerk C, de Wildt S C, Miedema H S, Valkenburg H A, Breedveld F C, Pols H A, Te Koppele J M, Sloos V F, Hofman A, Slagboom P E, van Duijn C M
机构信息
Gaubius Laboratory, and University Hospital, Leiden, The Netherlands.
出版信息
Arthritis Rheum. 1997 Oct;40(10):1760-5. doi: 10.1002/art.1780401006.
OBJECTIVE
To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes.
METHODS
Cases were selected from a population-based study on the presence of ROA of the knee or hip. Further radiographic analysis included scoring for spine and hand ROA. Controls, selected from the same population, were free of ROA in all joints.
RESULTS
The CRTM locus was significantly associated with hip ROA in men (odds ratio 0.50, 95% confidence interval 0.26-0.95). A significant association between ROA and the CRTL1 gene was not observed.
CONCLUSION
These results suggest that the CRTM locus may play a role in the sex- and joint site-specific pattern of ROA development.
目的
研究55至65岁男性和女性中影像学上明显的骨关节炎（ROA）是否与软骨基质蛋白（CRTM）和软骨连接蛋白（CRTL1）基因的特定等位基因或基因型相关。
方法
病例选自一项基于人群的关于膝关节或髋关节ROA存在情况的研究。进一步的影像学分析包括对脊柱和手部ROA进行评分。对照组选自同一人群，所有关节均无ROA。
结果
CRTM基因座与男性髋关节ROA显著相关（比值比0.50，95%置信区间0.26 - 0.95）。未观察到ROA与CRTL1基因之间存在显著关联。
结论
这些结果表明，CRTM基因座可能在ROA发展的性别和关节部位特异性模式中起作用。
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