Wong K, Gladman D D, Husted J, Long J A, Farewell V T
University of Toronto, and The Toronto Hospital, Ontario, Canada.
Arthritis Rheum. 1997 Oct;40(10):1868-72. doi: 10.1002/art.1780401021.
To identify the causes of death and mortality risk in patients with psoriatic arthritis (PsA) who were being followed up at a single outpatient clinic in Toronto, Ontario, Canada.
Patients enrolled in the PsA Clinic between 1978 and 1993 were compared with the general population of Ontario. Deaths were identified from the clinic database and through linkage with the provincial mortality database, and causes were confirmed by death certificates. A standardized mortality ratio (SMR) was computed, based on the assumption that patients lost to followup were alive at the end of the study.
Of the 428 patients with PsA (194 women and 234 men), 53 (26 women and 27 men) died. The 4 leading causes of death were diseases of the circulatory (36.2%) or respiratory (21.3%) system, malignant neoplasms (17.0%), and injuries/poisoning (14.9%). The SMR for the female cohort was 1.59, and for the men, it was 1.65, indicating a 59% and 65% increase in the death rate, respectively. Deaths due to respiratory causes were particularly increased in these patients.
The results suggest that this PsA Clinic outpatient population had an increased mortality risk.
确定在加拿大多伦多安大略省一家门诊诊所接受随访的银屑病关节炎（PsA）患者的死亡原因和死亡风险。
将1978年至1993年期间在PsA诊所登记的患者与安大略省的普通人群进行比较。通过诊所数据库并与省级死亡数据库建立联系来确定死亡情况，并通过死亡证明确认死因。基于失访患者在研究结束时仍存活的假设，计算标准化死亡率（SMR）。
在428例PsA患者（194例女性和234例男性）中，53例（26例女性和27例男性）死亡。4大主要死因是循环系统疾病（36.2%）或呼吸系统疾病（21.3%）、恶性肿瘤（17.0%）以及损伤/中毒（14.9%）。女性队列的SMR为1.59，男性为1.65，分别表明死亡率增加了59%和65%。这些患者中因呼吸系统原因导致的死亡尤其增加。
结果表明该PsA诊所门诊患者的死亡风险增加。
