Başbuğ M, Aygen E, Tayyar M, Kaya E, Demir I, Serin S
Department of Obstetrics and Gynecology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
J Reprod Med. 1997 Sep;42(9):600-2.
Although hydatidiform mole is not commonly encountered following ovulation induction, patients who have already had molar pregnancies are at increased risk of developing further molar diseases with worsening histologic characteristics. That fact underlies the ethical dilemma of repeat ovulation induction.
A 38-year-old woman, gravida 3, para 0, had three consecutive episodes of hydatidiform subsequent to clomiphene citrate and gonadotropin ovulation induction. She seems to be the first in the literature to develop three consecutive molar pregnancies without a normal intrauterine pregnancy.
Although ovulation induction commenced again in this patient after she gave informed consent, the risks underlying the ethical dilemma persist.
尽管在诱导排卵后葡萄胎并不常见，但既往有葡萄胎妊娠史的患者发生进一步葡萄胎疾病且组织学特征恶化的风险增加。这一事实构成了重复诱导排卵的伦理困境。
一名38岁女性，孕3产0，在使用枸橼酸氯米芬和促性腺激素诱导排卵后连续发生三次葡萄胎。她似乎是文献中首例连续三次发生葡萄胎妊娠而无正常宫内妊娠的患者。
尽管该患者在签署知情同意书后再次开始诱导排卵，但伦理困境背后的风险依然存在。
