Reynolds J S, Troy T L, Sevick-Muraca E M
Photon Migration Laboratory, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-1283, USA.
Biotechnol Prog. 1997 Sep-Oct;13(5):669-80. doi: 10.1021/bp970085g.
The ability to map interior optical properties of a highly scattering medium from exterior measurements of light propagation is afforded by optical tomography. In this communication, we describe the problem of optical tomography, the techniques of photon migration measurements necessary to accomplish it, and the development of multipixel measurements for rapid collection of optical signals. These multipixel measurements are shown to provide detection of contrast owing to the optical properties of absorption and fluorescence associated with dye-laden heterogeneities embedded in a tissue-like scattering medium. From these rapid measurements, successful reconstruction of an interior optical property map may now be possible with clinically realistic data acquisition times. Applications for the technology arise for biomedical optical imaging for the in vivo detection of disease and the diagnosis of tissue (bio-) chemistry.
光学断层扫描技术能够通过对光传播的外部测量来绘制高散射介质的内部光学特性。在本通讯中，我们描述了光学断层扫描的问题、实现该技术所需的光子迁移测量技术，以及用于快速采集光信号的多像素测量技术的发展。这些多像素测量显示，由于与嵌入组织样散射介质中的载有染料的异质性相关的吸收和荧光光学特性，能够检测到对比度。通过这些快速测量，现在有可能在临床实际的数据采集时间内成功重建内部光学特性图。该技术的应用出现在生物医学光学成像中，用于疾病的体内检测和组织（生物）化学诊断。
