Ong J L, Cardenas H L, Cavin R, Carnes D L
Department of Restorative Dentistry, University of Texas Health Science Center at San Antonio 78284, USA.
Int J Oral Maxillofac Implants. 1997 Sep-Oct;12(5):649-54.
In this study, the phenotypic expression of osteoblast progenitor cells, 2T9, on characterized titanium surfaces was examined in the presence of a bone morphogenetic protein-2 (BMP-2). X-ray photoelectron spectroscopy spectra indicated the presence of titanium dioxide on titanium surfaces, along with surface contaminants such as carbon and nitrogen. In the in vitro study, the activity of BMP-2-treated osteoblast cells on titanium surfaces was marked by significantly higher alkaline phosphatase-specific activity and 1,25 (OH2) vitamin D3-stimulated osteocalcin production when compared to the untreated cells on titanium surfaces.
在本研究中，在存在骨形态发生蛋白-2（BMP-2）的情况下，检测了成骨细胞祖细胞2T9在特定钛表面上的表型表达。X射线光电子能谱表明钛表面存在二氧化钛，以及碳和氮等表面污染物。在体外研究中，与钛表面未处理的细胞相比，BMP-2处理的钛表面成骨细胞的活性表现为碱性磷酸酶特异性活性显著更高，且1,25（OH2）维生素D3刺激的骨钙素产生量更多。
