Juczewska M, Chyczewski L
Department of Pathological Anatomy, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1997;42 Suppl 1:86-100.
The concept of angiogenesis and consecutive stages of the neovascularization processes under physiological and pathological conditions have been described. Angiogenesis is regulated by the different mechanisms which are in dynamic balance. The regulating components of these processes are the stimulating and inhibiting factors, the mediators of these reactions under influence of the host cell-tumor cell interaction. The role of angiogenesis in cancer development is connected with obtaining the angiogenic phenotype by tumor when the transformation from prevascular to vascular phase of neoplasm goes on. The further tumor growth and metastasis processes depend on neovascularization. Actual research trends in the field of angiogenesis have been presented in this paper. We need to know such markers of angiogenesis would be the most useful for doing research work and monitoring neoplasm diseases in clinics. Antiangiogenic management seems to be a new promising therapeutic concept in oncology.
血管生成的概念以及在生理和病理条件下新血管形成过程的连续阶段已被描述。血管生成受处于动态平衡的不同机制调节。这些过程的调节成分是刺激和抑制因子，它们是宿主细胞与肿瘤细胞相互作用影响下这些反应的介质。血管生成在癌症发展中的作用与肿瘤在从肿瘤的血管前期向血管期转变时获得血管生成表型有关。肿瘤的进一步生长和转移过程取决于新血管形成。本文介绍了血管生成领域的实际研究趋势。我们需要了解哪些血管生成标志物对开展研究工作和临床监测肿瘤疾病最有用。抗血管生成治疗似乎是肿瘤学中一个新的有前景的治疗概念。
