Chyczewska E, Mróz R M, Kowal E
Department of Pneumonology and Tuberculosis, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1997;42 Suppl 1:136-45.
The results of treatment and the survival time of lung cancer patients are strictly dependent on early diagnosis. Fiberoptic bronchoscopy and bronchoalveolar lavage (BAL) are the most effective diagnostic methods in cancer diagnosis. These methods allowed us to evaluate biological neoplastic markers at the site of the tumor. Using commercially available ELISA kits (Endogen) followed by ETI-system (SORIN) analysis we measured the IL-2 concentration in BALF of 36 non-small cell lung cancer (NSCLC) patients before (Gr. I) and after (Gr. II) surgery and 18 non-neoplastic lung disorder patients as a control group (6 cases of sarcoidosis and 12 cases of COPD). In BALF of Gr. I Macrophage percentage was higher (x = 74.125%), and lymphocyte percentage was lower (x = 15.875%) than in sarcoidosis x = 38.33% and x = 64.3% respectively. IL-2 of BALF was not detected in 83.4% of squamous cell lung cancer cases (Gr. I) before treatment. The average IL-2 BALF concentration of the remaining portion of this group was 80.49pg/ml/mg p. IL-2 was detected in Gr. II (x = 151.003 pg/ml/mg p.) after combined cancer resection. An inverse correlation was found between IL-2 BALF concentration and disease stage.
肺癌患者的治疗结果和生存时间严格依赖于早期诊断。纤维支气管镜检查和支气管肺泡灌洗（BAL）是癌症诊断中最有效的诊断方法。这些方法使我们能够在肿瘤部位评估生物肿瘤标志物。使用市售的ELISA试剂盒（Endogen），随后进行ETI系统（SORIN）分析，我们测量了36例非小细胞肺癌（NSCLC）患者手术前（I组）和手术后（II组）BALF中的IL-2浓度，以及18例非肿瘤性肺部疾病患者作为对照组（6例结节病和12例慢性阻塞性肺疾病）。在I组的BALF中，巨噬细胞百分比更高（x = 74.125%），淋巴细胞百分比更低（x = 15.875%），而在结节病中分别为x = 38.33%和x = 64.3%。治疗前83.4%的鳞状细胞肺癌病例（I组）未检测到BALF中的IL-2。该组其余部分的平均IL-2 BALF浓度为80.49pg/ml/mg p。联合癌症切除术后II组检测到IL-2（x = 151.003 pg/ml/mg p.）。发现IL-2 BALF浓度与疾病分期呈负相关。
