Zych J, Sakowicz A, Radzikowska E, Załeska J, Rowińska-Zakrzewska E
National Institute of Tuberculosis and Lung Diseases, Warsaw.
Rocz Akad Med Bialymst. 1997;42 Suppl 1:173-8.
It is believed that the tissue or serum expression of neuroendocrine markers in non small cell lung cancer patients can implicate better prognosis in cases undergoing chemotherapy. The aim of the study was to assess the value of NSE serum level for anticipation of the tumor response to chemotherapy. We found elevated serum level of NSE in 34 of 60 patients (56.7%) at the time of diagnosis of inoperable non small cell lung cancer, significantly more often in those presenting stage IV of disease. In 21.7% partial response and in another 21.7% minimal regression was found after chemotherapy. Treatment results revealed no significant differences in respect to NSE serum level, however 77% of patients achieving partial response had elevated serum level of NSE.
据信，非小细胞肺癌患者神经内分泌标志物的组织或血清表达可能提示接受化疗的患者预后较好。本研究的目的是评估NSE血清水平对预测肿瘤化疗反应的价值。我们发现，在60例无法手术的非小细胞肺癌患者中，有34例（56.7%）在诊断时血清NSE水平升高，在疾病处于IV期的患者中更为常见。化疗后发现21.7%的患者部分缓解，另有21.7%的患者轻微消退。治疗结果显示，NSE血清水平方面无显著差异，然而，77%达到部分缓解的患者血清NSE水平升高。
