肾移植中的维持性药理免疫抑制策略
Maintenance pharmacological immunosuppressive strategies in renal transplantation.
作者信息
Vella J P, Sayegh M H
机构信息
Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA.
出版信息
Postgrad Med J. 1997 Jul;73(861):386-90. doi: 10.1136/pgmj.73.861.386.
Abstract
Current maintenance immunosuppressive regimens for transplantation are based on three classes of drugs: corticosteroids, immunophilin-binding agents (eg, cyclosporin and tacrolimus), and antimetabolites (eg, azathioprine and mycophenolate). Drugs from the various classes inhibit the immune system at different points and are thus synergistic when used in combination.
摘要
目前用于移植的维持性免疫抑制方案基于三类药物
皮质类固醇、亲免素结合剂（如环孢素和他克莫司）以及抗代谢物（如硫唑嘌呤和霉酚酸酯）。各类药物在不同环节抑制免疫系统，因此联合使用时具有协同作用。
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本文引用的文献
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Trends in the use of glucocorticoids in renal transplantation.肾移植中糖皮质激素的使用趋势
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Elective cyclosporine withdrawal 1 year after renal transplantation.肾移植术后1年选择性停用环孢素。
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