Takahata M, Yonezawa M, Matsubara N, Watanabe Y, Narita H, Matsunaga T, Igarashi H, Kawahara M, Onodera S, Oishi Y
Research Laboratories, Toyama Chemical Co., Ltd, Japan.
J Antimicrob Chemother. 1997 Sep;40(3):383-6. doi: 10.1093/jac/40.3.383.
Antibacterial activity of quinolones against three species of coagulase-negative staphylococci was investigated. Tosufloxacin and sparfloxacin exhibited potent activities against Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus saprophyticus compared with other quinolones tested. From the analysis of the DNA sequence in the quinolone resistance-determining region (QRDR), greater than 80% homology was recognized in coagulase-negative staphylococci. A series residue was conserved in all six species at the position corresponding to position 84 in Staphylococcus aureus.
研究了喹诺酮类药物对三种凝固酶阴性葡萄球菌的抗菌活性。与其他受试喹诺酮类药物相比，妥舒沙星和司帕沙星对表皮葡萄球菌、溶血葡萄球菌和腐生葡萄球菌表现出强效活性。通过对喹诺酮耐药决定区（QRDR）的DNA序列分析，在凝固酶阴性葡萄球菌中发现了大于80%的同源性。在与金黄色葡萄球菌第84位相对应的位置上，所有六个菌种的一系列残基都是保守的。
