Chappell J S
Drug Enforcement Administration, Western Laboratory, San Francisco, CA 94105, USA.
Analyst. 1997 Aug;122(8):755-60. doi: 10.1039/a700122c.
A relatively rapid and simple means of enantiomer determination is described for the determination of methamphetamine, a common drug of abuse. The method employs the well known technique of infrared transmission spectrometry on solid samples dispersed within an alkali metal halide matrix. This approach exploits the solid-state, ion-exchange reaction between methamphetamine hydrochloride and a potassium iodide matrix and the subsequent formation of the hydriodide salt in situ. The infrared properties of the hydriodide salt are distinct for enantiomerically enriched and racemic samples, and therefore are readily distinguished by infrared transmission spectrometry. This technique uses materials and instrumentation that are generally available to most crime laboratories. The applicability of this method to some other amine drugs is discussed.
本文描述了一种相对快速且简单的对映体测定方法，用于测定甲基苯丙胺（一种常见的滥用药物）。该方法采用了在碱金属卤化物基质中分散的固体样品的红外透射光谱这一众所周知的技术。此方法利用了盐酸甲基苯丙胺与碘化钾基质之间的固态离子交换反应以及随后原位形成氢碘酸盐。氢碘酸盐的红外特性对于对映体富集和外消旋样品是不同的，因此通过红外透射光谱很容易区分。该技术使用的材料和仪器大多数犯罪实验室通常都有。本文还讨论了该方法对其他一些胺类药物的适用性。
