对用氢碘酸和红磷还原伪麻黄碱合成甲基苯丙胺过程中发现的杂质的研究。

Investigation of the impurities found in methamphetamine synthesised from pseudoephedrine by reduction with hydriodic acid and red phosphorus.

作者信息

Windahl K L, McTigue M J, Pearson J R, Pratt S J, Rowe J E, Sear E M

机构信息

School of Chemistry, La Trobe University, Bundoora, Victoria, Australia.

出版信息

Forensic Sci Int. 1995 Dec 18;76(2):97-114. doi: 10.1016/0379-0738(95)01803-4.

DOI:10.1016/0379-0738(95)01803-4

PMID:8566917

Abstract

The synthesis of methamphetamine from pseudoephedrine via the reduction with hydriodic acid and red phosphorus was studied and the impurities which were generated, along with the methamphetamine, were investigated. Some of the impurities found have been reported previously, while the diastereoisomers of N-methyl-N-(alpha- methylphenethyl)amino-1-phenyl-2-propanone and the cis-cinnamoyl derivative of methamphetamine are reported here for the first time. Further work on the sequence of reactions occurring in this reduction is also reported.

摘要

研究了通过用氢碘酸和红磷还原伪麻黄碱合成甲基苯丙胺的过程，并对与甲基苯丙胺一起产生的杂质进行了研究。发现的一些杂质此前已有报道，而N-甲基-N-(α-甲基苯乙)氨基-1-苯基-2-丙酮的非对映异构体和甲基苯丙胺的顺式肉桂酰衍生物则是首次在此报道。还报道了关于该还原反应中发生的反应顺序的进一步研究工作。