Karabela-Bouropoulou V, Antoniou D, Liapi-Avgeri G
University of Athens.
Arch Anat Cytol Pathol. 1996;44(5-6):263-8.
A case of malignant nerve sheath tumor with glandular differentiation in a patient with neurofibromatosis is presented. In the spindle celled areas the tumor cells reacted strongly with vimentin and S-100 protein, while the glandular epithelia reacted with EMA, cytokeratins (peptides 8, 19, and 20) and CEA, as well as a few of them also with chromogranin. Based on the results of immunohistochemical profile of the tumor cells, the differential diagnosis of this rare soft tissue tumor from biphasic synovial sarcoma with glands, as well as its distinction from any other spindle cell sarcoma with entrapped skin appendages could be greatly facilitated.
本文报告1例神经纤维瘤病患者发生的伴有腺分化的恶性神经鞘瘤。在梭形细胞区域，肿瘤细胞对波形蛋白和S-100蛋白呈强反应，而腺上皮对上皮膜抗原、细胞角蛋白（肽8、19和20）和癌胚抗原呈反应，其中少数腺上皮对嗜铬粒蛋白也呈反应。基于肿瘤细胞免疫组化特征的结果，可极大地有助于将这种罕见的软组织肿瘤与伴有腺体的双相滑膜肉瘤进行鉴别诊断，以及将其与任何其他伴有包埋皮肤附属器的梭形细胞肉瘤区分开来。
