Jacquemin-Sablon A
Unité de biochimie-enzymologie, URA 147 CNRS, Institut Gustave-Roussy, Villejuif.
Bull Cancer. 1997 Jul;84(7):741-6.
The "guardian of the genome" p53 is an essential modulator of the cellular response to cytotoxic agents. After introduction of DNA damages, the p53 protein prevents the cells to divide, either transiently by arresting their progression at the G1/S transition, or definitely by inducing apoptosis. In approximately half of the human tumors, mutations result in profound alterations of the p53 protein properties. In this work, the consequences of these alterations on the tumor cell sensitivity to chemotherapy are discussed.
“基因组守护者”p53是细胞对细胞毒性药物反应的重要调节因子。DNA损伤引入后，p53蛋白可阻止细胞分裂，要么通过在G1/S期转换时阻滞其进程而短暂阻止，要么通过诱导凋亡而彻底阻止。在大约一半的人类肿瘤中，突变导致p53蛋白特性发生深刻改变。在这项工作中，讨论了这些改变对肿瘤细胞化疗敏感性的影响。
