Seidenberg M, Hermann B P, Schoenfeld J, Davies K, Wyler A, Dohan F C
Department of Psychology, Chicago Medical School, Illinois 60064, USA.
Brain Cogn. 1997 Oct;35(1):132-48. doi: 10.1006/brcg.1997.0931.
The purpose of this investigation was to examine the issue of reorganization of verbal memory function following early insult to the left mesial temporal region. It was hypothesized that reorganization of memory function was most likely to occur in those patients with an early age of seizure onset who have a more limited degree of extra-hippocampal neuropathology. Fifty-four patients with epilepsy of unequivocal left temporal lobe origin were classified into four groups on the basis of the presence/absence of hippocampal sclerosis and degree of postoperative seizure relief. Measures of verbal learning and memory as well as nonmemory measures were administered both before and 6 to 8 months after anterior temporal lobectomy. Findings were consistent with the reorganization proposal. The clinical and theoretical significance of the findings are discussed.
本研究的目的是探讨左侧内侧颞叶区域早期受损后言语记忆功能重组的问题。研究假设，记忆功能重组最有可能发生在那些癫痫发作起始年龄较早且海马体外神经病理学程度较有限的患者中。54例明确起源于左侧颞叶的癫痫患者根据是否存在海马硬化及术后癫痫缓解程度分为四组。在颞叶前部切除术前以及术后6至8个月，均进行了言语学习和记忆测量以及非记忆测量。研究结果与重组假说一致。本文讨论了这些研究结果的临床和理论意义。
