• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A 1.2-megabase BAC/PAC contig spanning the 14q13 breakpoint of t(2; 14) in a mirror-image polydactyly patient.

作者信息

Matsumoto N, Soeda E, Ohashi H, Fujimoto M, Kato R, Tsujita T, Tomita H, Kondo S, Fukushima Y, Niikawa N

机构信息

Department of Human Genetics, Nagasaki University School of Medicine, Japan.

出版信息

Genomics. 1997 Oct 1;45(1):11-6. doi: 10.1006/geno.1997.4897.

DOI:10.1006/geno.1997.4897
PMID:9339355
Abstract

We previously assigned a 14q13 breakpoint of t(2; 14) in a patient with mirror-image polydactyly to a segment between two loci, AFM200ZH4 and D14S306, within a genetic distance of 0.6 cM. In the present study, we constructed a 1.2-Mb high-resolution physical map with a contig composed of 16 bacterial artificial chromosomes (BACs) and 6 P1-derived artificial chromosomes (PACs) at a region around the breakpoint, extending from D14S75 to D14S728 loci. Thirty-four novel sequence-tagged sites (STSs) were also characterized at this region. Of nine ESTs that had been mapped between D14S75 and D14S288, T99065 was confirmed to be in two BAC clones, B102 and B319. This BAC/PAC contig with STSs is useful for further genomic sequencing, for construction of a transcription map, and for the isolation of the putative gene for mirror-image polydactyly.

摘要

相似文献

1
A 1.2-megabase BAC/PAC contig spanning the 14q13 breakpoint of t(2; 14) in a mirror-image polydactyly patient.
Genomics. 1997 Oct 1;45(1):11-6. doi: 10.1006/geno.1997.4897.
2
A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet.在一名患有手足镜像多指（趾）畸形的患者中，一个新基因在t(2;14)的14q13断点处被破坏。
J Hum Genet. 2002;47(3):136-9. doi: 10.1007/s100380200015.
3
Molecular mapping of a translocation breakpoint at 14q13 in a patient with mirror-image polydactyly of hands and feet.
Hum Genet. 1997 Apr;99(4):450-3. doi: 10.1007/s004390050387.
4
Closing in on the BPES gene on 3q23: mapping of a de Novo reciprocal translocation t(3;4)(q23;p15.2) breakpoint within a 45-kb cosmid and mapping of three candidate genes, RBP1, RBP2, and beta'-COP, distal to the breakpoint.锁定位于3q23的BPES基因：在一个45 kb的黏粒内对一个新发相互易位t(3;4)(q23;p15.2)的断点进行定位，并对位于该断点远端的三个候选基因RBP1、RBP2和β'-COP进行定位。
Genomics. 1999 Apr 1;57(1):70-8. doi: 10.1006/geno.1999.5747.
5
A sequence-ready BAC/PAC contig and partial transcript map of approximately 1.5 Mb in human chromosome 17q25 comprising multiple disease genes.一个包含多个疾病基因的、约1.5兆碱基对的人类17号染色体q25区域的序列就绪BAC/PAC重叠群和部分转录图谱。
Genomics. 1999 Dec 1;62(2):242-50. doi: 10.1006/geno.1999.5991.
6
A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.一个覆盖遗传性前列腺癌1（HPC1）区域的6兆碱基对高分辨率物理图谱和转录图谱。
Genomics. 2000 Feb 15;64(1):1-14. doi: 10.1006/geno.1999.6051.
7
A 1.5-Mb physical map of the hidrotic ectodermal dysplasia (Clouston syndrome) gene region on human chromosome 13q11.人类13号染色体q11上汗孔角化性外胚层发育不良（克劳斯综合征）基因区域的1.5兆碱基物理图谱。
Genomics. 2000 Jul 15;67(2):232-6. doi: 10.1006/geno.2000.6202.
8
A 1-Mb BAC/PAC-based physical map of the autosomal recessive polycystic kidney disease gene (PKHD1) region on chromosome 6.基于1兆碱基细菌人工染色体/噬菌体人工染色体的6号染色体常染色体隐性多囊肾病基因（PKHD1）区域物理图谱。
Genomics. 1999 Apr 15;57(2):249-55. doi: 10.1006/geno.1999.5777.
9
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS): high-resolution physical and transcript map of the candidate region in chromosome region 13q11.夏尔沃 - 萨格奈常染色体隐性痉挛性共济失调（ARSACS）：13q11染色体区域候选区域的高分辨率物理图谱和转录图谱
Genomics. 1999 Dec 1;62(2):156-64. doi: 10.1006/geno.1999.6003.
10
An integrated map of human 6q22.3-q24 including a 3-Mb high-resolution BAC/PAC contig encompassing a QTL for fetal hemoglobin.人类6q22.3 - q24的综合图谱，包括一个3兆碱基的高分辨率细菌人工染色体/噬菌体人工染色体重叠群，该重叠群包含一个胎儿血红蛋白数量性状位点。
Genomics. 2000 Mar 15;64(3):264-76. doi: 10.1006/geno.2000.6133.

引用本文的文献

1
Current status of human chromosome 14.人类14号染色体的现状
J Med Genet. 2002 Feb;39(2):81-90. doi: 10.1136/jmg.39.2.81.
2
Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen.鉴定前顶体蛋白酶结合蛋白sp32前体作为一种人类癌胚抗原。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3282-7. doi: 10.1073/pnas.041625098.
3
Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements.嗅觉受体基因簇、基因组倒位多态性和常见染色体重排。
Am J Hum Genet. 2001 Apr;68(4):874-83. doi: 10.1086/319506. Epub 2001 Feb 26.
4
An optimized set of human telomere clones for studying telomere integrity and architecture.一组经过优化的用于研究端粒完整性和结构的人类端粒克隆。
Am J Hum Genet. 2000 Aug;67(2):320-32. doi: 10.1086/302998. Epub 2000 Jun 22.
5
Paroxysmal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1.阵发性运动诱发性舞蹈手足徐动症基因座定位于染色体16p11.2-q12.1。
Am J Hum Genet. 1999 Dec;65(6):1688-97. doi: 10.1086/302682.
6
Characterization of physical gap sizes at human telomeres.人类端粒处物理间隙大小的表征
Genome Res. 1999 Sep;9(9):888-94. doi: 10.1101/gr.9.9.888.
7
Isolation of BAC clones spanning the Xq22.3 translocation breakpoint in a lissencephaly patient with a de novo X;2 translocation.
J Med Genet. 1998 Oct;35(10):829-32. doi: 10.1136/jmg.35.10.829.