Noll D C, Genovese C R, Nystrom L E, Vazquez A L, Forman S D, Eddy W F, Cohen J D
Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA.
Magn Reson Med. 1997 Sep;38(3):508-17. doi: 10.1002/mrm.1910380320.
Functional magnetic resonance imaging (fMRI) using blood oxygenation contrast has rapidly spread into many application areas. In this paper, a new statistical model is used to evaluate the reliability of fMRI activation in a finger opposition motor paradigm for both within-session and between-session data and in a working memory paradigm for between-session data. A slice prescription procedure for between-session reproducibility is introduced. Estimates are made for the probabilities of correctly and falsely classifying voxels as active or inactive and receiver operator characteristic curves are generated. In the motor paradigm, estimated between-session reliability was found to be somewhat reduced relative to within-session reliability; however, this includes additional sources of variation and may not reflect intrinsically lower reliability. After matching false-positive classification probabilities, between-session reliability was found to be nearly identical for both motor and cognitive activation paradigms.
利用血氧对比度的功能磁共振成像（fMRI）已迅速扩展到许多应用领域。本文中，一种新的统计模型被用于评估在手指对掌运动范式中，会话内和会话间数据的fMRI激活可靠性，以及在工作记忆范式中会话间数据的fMRI激活可靠性。引入了一种用于会话间可重复性的切片定位程序。对体素正确和错误分类为激活或未激活的概率进行了估计，并生成了接收者操作特征曲线。在运动范式中，发现会话间估计的可靠性相对于会话内可靠性有所降低；然而，这包括了额外的变异来源，可能并不反映本质上较低的可靠性。在匹配假阳性分类概率后，发现运动和认知激活范式的会话间可靠性几乎相同。
