Yoo Seung-Schik, Wei Xingchang, Dickey Chandlee C, Guttmann Charles R G, Panych Lawrence P
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Int J Neurosci. 2005 Jan;115(1):55-77. doi: 10.1080/00207450490512650.
This article reports test-retest reproducibility of functional MRI (fMRI) measurement on brain activation elicited by auditory-cued sequential finger tapping. Eight right-handed volunteers participated in nine fMRI sessions, approximately eight weeks apart, for the duration of more than a year. The first scan session was repeated within a day to examine the intra-session reproducibility. The frequency of activation for neural substrates relevant to the task was constructed across the subjects and sessions. The spatial reproducibility was measured as the ratio of the size of the volume as well as its overlaps with respect to the first scan session from regions-of-interest in the selected motor circuitry. Consistent activation patterns between sessions and across subjects were observed in the sensorimotor areas such as the left primary, supplementary, and premotor areas, as well as in the right cerebellar areas without evidence of session-dependent trends. Quantitative analysis showed that the reproducibility measures varied within the range obtained from studies on fMRI reproducibility covering much shorter terms. Intra-session fMRI scans yielded slightly better reproducibility measures compared to the results obtained from other scan sessions. The findings suggest that the reproducible fMRI measurement can be obtained for long-term monitoring of brain function.
本文报告了功能磁共振成像（fMRI）测量听觉提示的顺序手指敲击诱发脑激活的重测再现性。八名右利手志愿者参加了九个fMRI扫描时段，间隔约八周，持续时间超过一年。第一个扫描时段在一天内重复进行，以检查时段内的再现性。构建了与任务相关的神经基质的激活频率，并涉及所有受试者和扫描时段。空间再现性通过所选运动神经回路感兴趣区域的体积大小及其与第一次扫描时段的重叠率来衡量。在感觉运动区域，如左侧初级、辅助和运动前区，以及右侧小脑区域，观察到各时段之间和所有受试者之间一致的激活模式，且没有明显的时段依赖性趋势。定量分析表明，再现性测量值在fMRI再现性研究的短得多的时间段内得到的范围内变化。与其他扫描时段的结果相比，时段内fMRI扫描产生的再现性测量值略好。研究结果表明，可以获得可重复的fMRI测量值，用于长期监测脑功能。
