Fenger C
Acta Pathol Microbiol Scand A. 1979 Sep;87A(5):379-86. doi: 10.1111/j.1699-0463.1979.tb00066.x.
The location and extent of the anal transitional zone (ATZ) were investigated in the age group typical for anal canal carcinomas. The methods used were macroscopic determination after whole-mount staining with Alcian-dyes as well as conventional histological technique. The results show that the epithelial variants may be found over a larger area than previously reported, namely from 6 mm below to 20 mm above the dentate line. Variations in location and extent of the ATZ are described, as well as the frequent finding of mature squamous epithelium high in the anal canal. The significance of the findings in relation to the special types of anal canal carcinomas is discussed, and on the basis of the macroscopic definition of the canal, as well as the histological observations in this study, it is proposed that anal canal carcinomas should be defined as tumours partly or totally located within a distance of 2 cm above the dentate line.
在肛管癌的典型年龄组中，对肛管过渡区（ATZ）的位置和范围进行了研究。使用的方法包括阿尔辛染料全层染色后的宏观测定以及传统组织学技术。结果表明，上皮变体的发现范围可能比之前报道的更大，即从齿状线以下6毫米到以上20毫米。描述了ATZ位置和范围的变化，以及在肛管较高位置频繁发现成熟鳞状上皮的情况。讨论了这些发现与特殊类型肛管癌的关系，并且基于肛管的宏观定义以及本研究中的组织学观察结果，建议将肛管癌定义为部分或完全位于齿状线以上2厘米范围内的肿瘤。
