Jenkins W L, Davis L E, Boulos B M
Am J Vet Res. 1975 Dec;36(12):1771-6.
The rates at which pentobarbital, salicylate, antipyrine, and quinine were transferred from the rumen of intact, conscious goats were measured. The rates at which the same drugs diffused from the blood plasma (under conditions of constant drug concentration) into the ruminal solution were also evaluated. These compounds were absorbed by simple diffusion, and the rates of transfer were a function of pH of the intraruminal solution. The diffusion of drugs from plasma into the reticulorumen allowed steady-state distributions to be established in some goats. The theoretical and observed steady-state distributions were compared. There were good correlations for pentobarbital and antipyrine, but not for salicylate and quinine. These findings confirm in vivo the general principles of drug transfer across ruminal epithelium that were derived from previous studies conducted in vitro.
测定了戊巴比妥、水杨酸盐、安替比林和奎宁从完整、清醒山羊瘤胃的转运速率。还评估了相同药物在血浆中（在药物浓度恒定的条件下）向瘤胃液扩散的速率。这些化合物通过简单扩散被吸收，转运速率是瘤胃内溶液pH值的函数。药物从血浆向网瘤胃的扩散使一些山羊建立了稳态分布。比较了理论和观察到的稳态分布。戊巴比妥和安替比林有良好的相关性，但水杨酸盐和奎宁没有。这些发现从体内证实了先前体外研究得出的药物跨瘤胃上皮转运的一般原则。
