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[精神分裂症患者成瘾药物的使用模式及使用动机]

[Consumption patterns and motivation for use of addictive drugs in schizophrenic patients].

作者信息

Lambert M, Haasen C, Mass R, Krausz M

机构信息

Psychiatrische und Nervenklinik Universitätskrankenhaus Eppendorf, Hamburg.

出版信息

Psychiatr Prax. 1997 Jul;24(4):185-9.

PMID:9340658
Abstract

In particular studies conducted in the U.S. display a tendency for schizophrenics to combine hallucinogens and amphetamines, whereas other studies report on a combination of psychotropic substances with a similar range of action. Influencing negative symptoms is reported to be the motivation for consumption. A total of 222 patients with a schizophrenic disorder (F2) and addiction (F1) were examined. The main substance was alcohol (F10.1 or F10.2; 52.2%), followed by cannabis (F12; 25%), opiates (F11; 4.1%), sedatives or hypnotics (F13; 2.7%) and cocaine (F16; 0.5%). A multiple drug use (F19) is reported by 14% of them. The most frequent combination was alcohol and cannabis, whereas hallucinogens and amphetamines were only rarely combined. Actual multiple consumption was reported by 55% of the patients, while lifetime multiple consumption applied to 72%. The motivation seems to be an unspecified sedation of unpleasant affective symptoms of schizophrenia. The most frequently seen combinations do not correlate with the reports published in the literature. The great variations in motivation seem to mainly reflect the importance of the availability of the substance.

摘要

特别是在美国进行的研究显示,精神分裂症患者有将致幻剂和安非他明混合使用的倾向,而其他研究则报告了一系列具有相似作用范围的精神活性物质的混合使用情况。据报道,影响阴性症状是使用这些物质的动机。总共对222名患有精神分裂症障碍(F2)和成瘾症(F1)的患者进行了检查。主要物质是酒精(F10.1或F10.2;52.2%),其次是大麻(F12;25%)、阿片类药物(F11;4.1%)、镇静剂或催眠药(F13;2.7%)以及可卡因(F16;0.5%)。其中14%的患者报告有多种药物使用情况(F19)。最常见的组合是酒精和大麻,而致幻剂和安非他明很少混合使用。55%的患者报告有实际的多种物质消费情况,而终生多种物质消费情况则适用于72%的患者。其动机似乎是对精神分裂症不愉快情感症状进行一种未明确说明的镇静。最常见的组合与文献中发表的报告不相关。动机方面的巨大差异似乎主要反映了物质可得性的重要性。

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