Wollin D, Menninger H
1. Medizinische Klinik BRK Rheuma-Zentrum, Bad Abbach.
Z Rheumatol. 1997 May-Jun;56(3):114-26. doi: 10.1007/s003930050027.
Therapy of rheumatoid arthritis with a combination of several disease-modifying drugs aims to better control of the disease than achievable by monotherapy. Subsequent to a paper written two years ago, this publication reviews studies dealing with combination therapy issued mainly in 1995 and 1996. Most studies deal with MTX as one of the partners. Beneficial results were reported for the combination of methotrexate with antimalarials, cyclosporine or sulfasalazine. The triple combination of methotrexate with hydroxychloroquine and azathioprine is especially promising although the studies presented up to now are still insufficient for its final assessment, due to methodologic problems. Similarly, the value of the combination of sulfasalazine with injectable gold, of sulfasalazine with methotrexate and hydroxychloroquine, or of methotrexate with injectable gold is still uncertain.
使用几种改善病情药物联合治疗类风湿性关节炎的目的是比单一疗法能更好地控制疾病。继两年前的一篇论文之后，本出版物回顾了主要在1995年和1996年发表的有关联合治疗的研究。大多数研究将甲氨蝶呤作为联合用药之一。甲氨蝶呤与抗疟药、环孢素或柳氮磺胺吡啶联合使用已报告有有益效果。甲氨蝶呤与羟氯喹和硫唑嘌呤的三联组合尤其有前景，尽管由于方法学问题，目前所呈现的研究仍不足以进行最终评估。同样，柳氮磺胺吡啶与注射用金、柳氮磺胺吡啶与甲氨蝶呤和羟氯喹，或甲氨蝶呤与注射用金联合使用的价值仍不确定。
