Huhn J C, Nelson D R
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, USA.
Zentralbl Veterinarmed A. 1997 Aug;44(6):361-71. doi: 10.1111/j.1439-0442.1997.tb01120.x.
Electromyographic (EMG) recordings of the abomasal corpus, pyloric antrum and proximal duodenum were made from six goats for 2 h periods before and after administration of 0.5 mg/kg metoclopramide intravenously or intramuscularly. Analog EMG signal was transformed via a computer program to digital data. The percentage change in electrical activity was determined by comparing the electrical activity following administration of IV or IM metoclopramide with the electrical activity of the control periods for the abomasal corpus, pyloric antrum and proximal duodenum. Metoclopramide caused a significant, time-dependent increase in duodenal electrical activity following either route of administration. This increase in duodenal electrical activity coincided with peak plasma levels of metoclopramide until its decline below 100 ng/ml in plasma. There was a significant biphasic increase in electrical activity of the abomasal corpus and pyloric antrum following IM administration of metoclopramide. The first phase lasted approximately 5 min and was followed by a longer period (approximately 20 min) of diminished electrical activity. A second phase of increased electrical activity occurred approximately 40-60 min after initial IM injection of metoclopramide. It is uncertain whether this increase was drug-mediated or endogenously-triggered. Similar increases in corpus and antral electrical activity were present following IV metoclopramide administration, though early increases were not statistically significant. Overall, the percentage changes in electrical activity correlated well with predicted peak plasma levels of metoclopramide only in the duodenum. This correlation was limited to approximately 5 min after IV and 15 min after IM metoclopramide administration.
对六只山羊的皱胃体、幽门窦和十二指肠近端进行肌电图（EMG）记录，记录时间为静脉或肌肉注射0.5mg/kg甲氧氯普胺前后各2小时。模拟EMG信号通过计算机程序转换为数字数据。通过比较静脉或肌肉注射甲氧氯普胺后的电活动与皱胃体、幽门窦和十二指肠近端对照期的电活动，确定电活动的百分比变化。无论采用哪种给药途径，甲氧氯普胺均可使十二指肠电活动显著增加，且呈时间依赖性。十二指肠电活动的增加与甲氧氯普胺的血浆峰值水平一致，直至其在血浆中的水平降至100ng/ml以下。肌肉注射甲氧氯普胺后，皱胃体和幽门窦的电活动出现显著的双相增加。第一阶段持续约5分钟，随后是较长时间（约20分钟）的电活动减弱。在首次肌肉注射甲氧氯普胺后约40 - 60分钟，出现电活动增加的第二阶段。尚不确定这种增加是药物介导的还是内源性触发的。静脉注射甲氧氯普胺后，皱胃体和胃窦的电活动也有类似增加，尽管早期增加无统计学意义。总体而言，电活动的百分比变化仅在十二指肠中与甲氧氯普胺的预测血浆峰值水平有良好的相关性。这种相关性仅限于静脉注射甲氧氯普胺后约5分钟和肌肉注射后15分钟。
