Roussel A J, Brumbaugh G W, Waldron R C, Baird A N
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Am J Vet Res. 1994 Jan;55(1):111-5.
Effects of the following treatments on abomasal and duodenal myoelectric activity in yearling cattle were studied: 2 ml of 0.9% sodium chloride solution (NACL); 0.07 mg of bethanechol (BET)/kg of body weight; 0.1 mg of metoclopramide (MET)/kg; and 0.07 mg of bethanechol and 0.1 mg of metoclopramide (BETMET)/kg. All treatments were administered SC during the early part of phase I of the migrating myoelectric complex. Myoelectric signals were recorded for 4 hours after administration of the treatments from 1 electrode in the antrum and 3 electrodes in the duodenum. For the antral spike rate (ASR), there was no significant difference among treatments during the first hour, but the ASR was significantly (P < 0.05) greater during hours 2 to 4 after treatment with BETMET, compared with ASR for MET alone. The duodenal spike rate (DSR) was significantly (P < 0.05) greater during the first hour after administration of BETMET than after the other treatments. After administration of BET, DSR was significantly (P < 0.05) greater than after MET or NACL. There was no difference in DSR after MET, compared with DSR after NACL. There was no significant difference in DSR among treatments during the second and third hours. The total antegrade propagating spike (TAPS) count was greater after administration of BETMET in all hours, compared with the other treatments. The ratio of TAPS to total spikes on the orad-most duodenal electrode was significantly (P < 0.05) greater after BETMET during hours 1 and 2.
2毫升0.9%氯化钠溶液（NACL）；0.07毫克氨甲酰甲胆碱（BET）/千克体重；0.1毫克甲氧氯普胺（MET）/千克；以及0.07毫克氨甲酰甲胆碱和0.1毫克甲氧氯普胺（BETMET）/千克。所有处理均在移行性肌电复合波I期早期经皮下注射。处理给药后，从胃窦1个电极和十二指肠3个电极记录4小时的肌电信号。对于胃窦峰频率（ASR），处理后第1小时各处理间无显著差异，但与单独使用MET相比，BETMET处理后第2至4小时的ASR显著更高（P<0.05）。给药后第1小时，BETMET组的十二指肠峰频率（DSR）显著高于其他处理组（P<0.05）。给予BET后，DSR显著高于MET或NACL处理后（P<0.05）。MET处理后的DSR与NACL处理后的DSR无差异。在第2和第3小时，各处理间的DSR无显著差异。与其他处理相比，所有时间点给予BETMET后的顺行传播峰总数（TAPS）均更高。在第1和第2小时，BETMET处理后的TAPS与十二指肠最近端电极上的总峰数之比显著更高（P<0.05）。
