在血小板微粒体中鉴定出一种可将前列腺素内过氧化物转化为血栓素A2的酶。
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides.
作者信息
Needleman P, Moncada S, Bunting S, Vane J R, Hamberg M, Samuelsson B
出版信息
Nature. 1976 Jun 17;261(5561):558-60. doi: 10.1038/261558a0.
DOI:10.1038/261558a0
PMID:934294
Abstract
The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting strips of rabbit aorta. This substance has the same characteristics as thromboxane A2, and can be distinguished from other products of arachidonic acid metabolism by differential bioassay.
摘要
马和人血小板的微粒体部分含有一种酶，该酶可将前列腺素环内过氧化物（PGG2或PGH2）转化为一种在使兔主动脉条收缩方面更具效力的物质。这种物质具有与血栓素A2相同的特性，并且可以通过差异生物测定法与花生四烯酸代谢的其他产物区分开来。
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