血栓素A2和前列腺素H2：猪冠状动脉的强效刺激物。
Thromboxane A2 and prostaglandin H2: potent stimulators of the swine coronary artery.
作者信息
Svensson J, Hamberg M
出版信息
Prostaglandins. 1976 Dec;12(6):943-50. doi: 10.1016/0090-6980(76)90128-3.
PMID:1005743
Abstract
Thromboxane A2 was generated by incubation of arachidonic acid with a suspension of human platelets. The filtrate contained 266 +/- 46 ng/ml (n=10) of thromboxane A2 and 25 ng/ml or less of prostaglandin endoperoxides (prostaglandins G2+H2). Thromboxane A2 was 2-10 times more potent than prostaglandin H2 and 9-102 times and 26-308 times more potent than prostaglandins E2 and F2alpha, respectively, in causing contractions of the superfused swine coronary artery.
摘要
通过将花生四烯酸与人血小板悬液一起孵育来生成血栓素A2。滤液中含有266±46 ng/ml（n = 10）的血栓素A2以及25 ng/ml或更少的前列腺素内过氧化物（前列腺素G2 + H2）。在引起灌注猪冠状动脉收缩方面，血栓素A2的效力分别比前列腺素H2高2至10倍，比前列腺素E2高9至102倍，比前列腺素F2α高26至308倍。
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