具有完整基因组RNA 3'非编码区缺失的复制能力的小RNA病毒。
Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions.
作者信息
Todd S, Towner J S, Brown D M, Semler B L
机构信息
Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine 92697, USA.
出版信息
J Virol. 1997 Nov;71(11):8868-74. doi: 10.1128/JVI.71.11.8868-8874.1997.
Abstract
The genomic RNA 3' noncoding region is believed to be a major cis-acting molecular genetic determinant for regulating picornavirus negative-strand RNA synthesis by promoting replication complex recognition. We report the replication of two picornavirus RNAs harboring complete deletions of the genomic RNA 3' noncoding regions. Our results suggest that while specific 3'-terminal RNA sequences and/or secondary structures may have evolved to promote or regulate negative-strand RNA synthesis, the basic mechanism of replication initiation is not strictly template specific and may rely primarily upon the proximity of newly translated viral replication proteins to the 3' terminus of template RNAs within tight membranous replication complexes.
摘要
基因组RNA 3'非编码区被认为是通过促进复制复合物识别来调节小核糖核酸病毒负链RNA合成的主要顺式作用分子遗传决定因素。我们报道了两种基因组RNA 3'非编码区完全缺失的小核糖核酸病毒RNA的复制情况。我们的结果表明，虽然特定的3'末端RNA序列和/或二级结构可能已经进化以促进或调节负链RNA合成，但复制起始的基本机制并非严格的模板特异性，可能主要依赖于新翻译的病毒复制蛋白在紧密的膜性复制复合物中与模板RNA 3'末端的接近程度。
相似文献
1
Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions.
J Virol. 1997 Nov;71(11):8868-74. doi: 10.1128/JVI.71.11.8868-8874.1997.
2
An authentic 3' noncoding region is necessary for efficient poliovirus replication.
J Virol. 2005 Sep;79(18):11962-73. doi: 10.1128/JVI.79.18.11962-11973.2005.
3
RNA-protein interactions directed by the 3' end of human rhinovirus genomic RNA.
J Virol. 1995 Jun;69(6):3605-14. doi: 10.1128/JVI.69.6.3605-3614.1995.
4
Mechanistic intersections between picornavirus translation and RNA replication.
Adv Virus Res. 2011;80:1-24. doi: 10.1016/B978-0-12-385987-7.00001-4.
5
Non-template functions of viral RNA in picornavirus replication.
Curr Opin Virol. 2011 Nov;1(5):339-46. doi: 10.1016/j.coviro.2011.09.005.
6
Replication of poliovirus RNA and subgenomic RNA transcripts in transfected cells.
J Virol. 1992 Nov;66(11):6480-8. doi: 10.1128/JVI.66.11.6480-6488.1992.
7
Identification of a cis-acting replication element within the poliovirus coding region.
J Virol. 2000 May;74(10):4590-600. doi: 10.1128/jvi.74.10.4590-4600.2000.
8
The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication.
RNA. 1998 Dec;4(12):1569-84. doi: 10.1017/s1355838298981006.
9
Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation.
J Virol. 2017 Jul 27;91(16). doi: 10.1128/JVI.00423-17. Print 2017 Aug 15.
10
Requirements for assembly of poliovirus replication complexes and negative-strand RNA synthesis.
J Virol. 2001 Apr;75(8):3841-50. doi: 10.1128/JVI.75.8.3841-3850.2001.
引用本文的文献
1
The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus.
PLoS Pathog. 2024 Dec 23;20(12):e1012283. doi: 10.1371/journal.ppat.1012283. eCollection 2024 Dec.
2
The Roles of the 5' and 3' Untranslated Regions in Human Astrovirus Replication.
Viruses. 2023 Jun 20;15(6):1402. doi: 10.3390/v15061402.
3
Tolerance of Senecavirus A to Mutations in Its Kissing-Loop or Pseudoknot Structure Computationally Predicted in 3' Untranslated Region.
Front Microbiol. 2022 May 30;13:889480. doi: 10.3389/fmicb.2022.889480. eCollection 2022.
4
Recent Progress on Functional Genomics Research of Enterovirus 71.
Virol Sin. 2019 Feb;34(1):9-21. doi: 10.1007/s12250-018-0071-9. Epub 2018 Dec 14.
5
The Functional Role of the 3' Untranslated Region and Poly(A) Tail of Duck Hepatitis A Virus Type 1 in Viral Replication and Regulation of IRES-Mediated Translation.
Front Microbiol. 2018 Sep 25;9:2250. doi: 10.3389/fmicb.2018.02250. eCollection 2018.
6
Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells.
mBio. 2018 Sep 4;9(5):e01669-18. doi: 10.1128/mBio.01669-18.
7
Emergency Services of Viral RNAs: Repair and Remodeling.
Microbiol Mol Biol Rev. 2018 Mar 14;82(2). doi: 10.1128/MMBR.00067-17. Print 2018 Jun.
8
Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs.
Viruses. 2016 Feb 4;8(2):39. doi: 10.3390/v8020039.
9
Mutational Disruption of cis-Acting Replication Element 2C in Coxsackievirus B3 Leads to 5'-Terminal Genomic Deletions.
J Virol. 2015 Dec;89(23):11761-72. doi: 10.1128/JVI.01308-15. Epub 2015 Sep 9.
10
Initiation of protein-primed picornavirus RNA synthesis.
Virus Res. 2015 Aug 3;206:12-26. doi: 10.1016/j.virusres.2014.12.028. Epub 2015 Jan 12.
本文引用的文献
1
THE DRUG-REQUIRING PHASE IN THE GROWTH OF DRUG-DEPENDENT ENTEROVIRUSES.
Proc Natl Acad Sci U S A. 1963 Aug;50(2):183-90. doi: 10.1073/pnas.50.2.183.
2
Poliovirus-induced RNA polymerase and the effects of virus-specific inhibitors on its production.
Proc Natl Acad Sci U S A. 1963 Jun;49(6):843-9. doi: 10.1073/pnas.49.6.843.
3
4
Translation and replication properties of the human rhinovirus genome in vivo and in vitro.
Virology. 1997 Mar 3;229(1):90-7. doi: 10.1006/viro.1996.8416.
5
An RNA tertiary structure in the 3' untranslated region of enteroviruses is necessary for efficient replication.
J Virol. 1997 Mar;71(3):2363-70. doi: 10.1128/JVI.71.3.2363-2370.1997.
6
Kissing of the two predominant hairpin loops in the coxsackie B virus 3' untranslated region is the essential structural feature of the origin of replication required for negative-strand RNA synthesis.
J Virol. 1997 Jan;71(1):686-96. doi: 10.1128/JVI.71.1.686-696.1997.
7
Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation.
J Virol. 1997 Jan;71(1):578-85. doi: 10.1128/JVI.71.1.578-585.1997.
8
9
Structure-infectivity analysis of the human rhinovirus genomic RNA 3' non-coding region.
Nucleic Acids Res. 1996 Jun 1;24(11):2133-42. doi: 10.1093/nar/24.11.2133.
10
Mutations in the poliovirus 3CD proteinase S1-specificity pocket affect substrate recognition and RNA binding.
Virology. 1996 Apr 1;218(1):1-13. doi: 10.1006/viro.1996.0160.
Zotero 插件