肠道病毒 71 型功能基因组学研究进展。
Recent Progress on Functional Genomics Research of Enterovirus 71.
机构信息
Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
出版信息
Virol Sin. 2019 Feb;34(1):9-21. doi: 10.1007/s12250-018-0071-9. Epub 2018 Dec 14.
Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Studying EV71 protein function is essential for elucidating the EV71 replication process and developing anti-EV71 drugs and vaccines. In this review, we summarized the recent progress in the studies of EV71 non-coding regions (5' UTR and 3' UTR) and all structural and nonstructural proteins, especially the key motifs involving in viral infection, replication, and immune regulation. This review will promote our understanding of EV71 virus replication and pathogenesis, and will facilitate the development of novel drugs or vaccines to treat EV71.
肠道病毒 71 型（EV71）是引起手足口病（HFMD）的主要病原体之一。由 EV71 感染引起的 HFMD 大多为自限性疾病；然而，一些感染可导致严重的神经系统疾病，如无菌性脑膜炎、脑干脑炎，甚至死亡。目前尚无用于预防和治疗手足口病的有效临床药物。研究 EV71 蛋白功能对于阐明 EV71 复制过程以及开发抗 EV71 药物和疫苗至关重要。在这篇综述中，我们总结了 EV71 非编码区（5'UTR 和 3'UTR）和所有结构蛋白和非结构蛋白的最新研究进展，特别是涉及病毒感染、复制和免疫调节的关键基序。这篇综述将促进我们对 EV71 病毒复制和发病机制的理解，并有助于开发新型药物或疫苗来治疗 EV71。
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