乙型肝炎病毒RNA通过类Rev途径的输出：再生肝抑制因子IkappaBα的抑制作用
Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.
作者信息
Roth J, Dobbelstein M
机构信息
ZIM, Gastroenterologie, Klinikum der Universität Marburg, Germany.
出版信息
J Virol. 1997 Nov;71(11):8933-9. doi: 10.1128/JVI.71.11.8933-8939.1997.
Abstract
Nuclear export of hepatitis B virus (HBV) RNA is mediated by a specific RNA element but, in contrast to lentivirus genomic RNA, does not depend on viral proteins. We show that nonetheless, the export of HBV RNA can be blocked by competitive inhibitors of Rev-mediated lentivirus RNA export, suggesting that the export pathways of both viral species share components and might be driven by the same nuclear export machinery. HBV RNA export is also inhibited by overexpression of IkappaB alpha, as reported previously for the export of human immunodeficiency virus RNA. Since IkappaB alpha is strongly overexpressed during liver regeneration, its inhibition of HBV RNA export might contribute to elimination or silent persistence of HBV.
摘要
乙型肝炎病毒（HBV）RNA的核输出由特定的RNA元件介导，但与慢病毒基因组RNA不同的是，它不依赖病毒蛋白。我们发现，尽管如此，HBV RNA的输出可被Rev介导的慢病毒RNA输出的竞争性抑制剂所阻断，这表明这两种病毒的输出途径共享一些成分，并且可能由相同的核输出机制驱动。如先前关于人类免疫缺陷病毒RNA输出的报道一样，IkappaBα的过表达也会抑制HBV RNA的输出。由于IkappaBα在肝脏再生过程中会强烈过表达，其对HBV RNA输出的抑制作用可能有助于HBV的清除或隐匿性持续存在。
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本文引用的文献
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The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export.与HIV-1 RRE不同，猿猴逆转录病毒1型组成型转运元件利用细胞mRNA输出所需的因子。
Curr Biol. 1997 Sep 1;7(9):619-28. doi: 10.1016/s0960-9822(06)00288-0.
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Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence.由类rev信号序列介导的E1B 55千道尔顿和E4 34千道尔顿腺病毒癌蛋白的核输出。
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Distinct domains of IkappaB-alpha inhibit human immunodeficiency virus type 1 replication through NF-kappaB and Rev.IκB-α的不同结构域通过NF-κB和Rev抑制1型人类免疫缺陷病毒复制。
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A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus.核孔蛋白FG重复结构域在1型人类免疫缺陷病毒Rev蛋白和RNA从细胞核输出中的作用。
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The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.尽管细胞毒性T淋巴细胞反应持续活跃，但乙肝病毒在患者从急性病毒性肝炎中康复后仍会持续数十年。
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The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal.人类1型T细胞白血病病毒转录后反式激活因子Rex含有一个核输出信号。
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