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人类1型T细胞白血病病毒转录后反式激活因子Rex含有一个核输出信号。

The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal.

作者信息

Palmeri D, Malim M H

机构信息

Graduate Group in Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.

出版信息

J Virol. 1996 Sep;70(9):6442-5. doi: 10.1128/JVI.70.9.6442-6445.1996.

DOI:10.1128/JVI.70.9.6442-6445.1996
PMID:8709278
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190676/
Abstract

The Rex protein of human T-cell leukemia virus type 1 is required for the nuclear export of unspliced viral mRNA and, therefore, for virus replication. In this manuscript, we demonstrate that Rex shuttles between the nucleus and the cytoplasm and that its activation domain constitutes a nuclear export signal that specifies efficient transport to the cytoplasm. These findings are consistent with a model for Rex-mediated trans-activation in which Rex-viral mRNA complexes are targeted for nuclear export by the direct action of the activation domain.

摘要

人类T细胞白血病病毒1型的Rex蛋白是未剪接病毒mRNA核输出所必需的，因此也是病毒复制所必需的。在本论文中，我们证明Rex在细胞核和细胞质之间穿梭，其激活结构域构成一个核输出信号，该信号指定向细胞质的有效转运。这些发现与Rex介导的反式激活模型一致，在该模型中，Rex-病毒mRNA复合物通过激活结构域的直接作用被靶向进行核输出。

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The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal.人类1型T细胞白血病病毒转录后反式激活因子Rex含有一个核输出信号。
J Virol. 1996 Sep;70(9):6442-5. doi: 10.1128/JVI.70.9.6442-6445.1996.
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Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals.1型人类免疫缺陷病毒、维斯纳病毒和马传染性贫血病毒Rev蛋白的核运输：可转移核输出信号家族的鉴定
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