Gorbachevskaia N L, Denisova L V
Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(8):33-7.
30 patients (4-22 years old) and their 12 mothers were examined by means of method of electroencephalography (EEG). Healthy individuals of corresponding age were included in the control group. EEG changes of the same type were observed in all the patients with syndrome of fragile X-chromosome: reduction of occipital alpha-rhythm, prevalence of theta-rhythm in central-parietal and central frontal regions as well as epileptoid activity in parietal and central-parietal cortical regions. These peculiarities could be considered as the markers in syndrome's diagnostics. EEG of mothers (heterozygous carriers of mutant gene) were characterised by considerable variations: increase of rolandic rhythm's presentation in central cortical zones, accumulation of hypersynchronous EEG, increase of rhythmical theta-activity, etc. EEG of mother with shift-like schizophrenia resembled one of proband in one case.
对30名患者（4至22岁）及其12名母亲采用脑电图（EEG）方法进行了检查。对照组纳入了相应年龄的健康个体。所有脆性X染色体综合征患者均观察到相同类型的脑电图变化：枕部α节律降低，中央顶叶和中央额叶区域θ节律占优势，以及顶叶和中央顶叶皮质区域的类癫痫样活动。这些特征可被视为该综合征诊断的标志物。母亲（突变基因的杂合携带者）的脑电图表现出相当大的差异：中央皮质区罗兰节律出现增加、脑电图超同步化积聚、节律性θ活动增加等。在1例病例中，患有类似精神分裂症症状的母亲的脑电图与先证者的脑电图相似。
