Department of Psychiatry, University of Texas Southwestern, Dallas, TX, USA.
Department of Pediatrics, University of Texas Southwestern, Dallas, TX, USA.
J Neurodev Disord. 2013 Sep 16;5(1):24. doi: 10.1186/1866-1955-5-24.
Autism spectrum disorders (ASD) are a group of complex and heterogeneous developmental disorders involving multiple neural system dysfunctions. In an effort to understand neurophysiological substrates, identify etiopathophysiologically distinct subgroups of patients, and track outcomes of novel treatments with translational biomarkers, EEG (electroencephalography) studies offer a promising research strategy in ASD. Resting-state EEG studies of ASD suggest a U-shaped profile of electrophysiological power alterations, with excessive power in low-frequency and high-frequency bands, abnormal functional connectivity, and enhanced power in the left hemisphere of the brain. In this review, we provide a summary of recent findings, discuss limitations in available research that may contribute to inconsistencies in the literature, and offer suggestions for future research in this area for advancing the understanding of ASD.
自闭症谱系障碍（ASD）是一组复杂且异质的发育障碍，涉及多个神经系统功能障碍。为了理解神经生理学基础，确定具有不同病因病理生理亚组的患者，以及通过转化生物标志物跟踪新型治疗方法的结果，脑电图（EEG）研究为 ASD 提供了一种很有前途的研究策略。ASD 的静息态 EEG 研究表明，电生理功率变化呈 U 形分布，低频和高频带的功率过高，功能连接异常，大脑左半球的功率增强。在这篇综述中，我们总结了最近的发现，讨论了现有研究中的局限性，这些局限性可能导致文献中的不一致，并为该领域的进一步研究提供了建议，以推进对 ASD 的理解。
