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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Beubler E, Lembeck F

Naunyn Schmiedebergs Arch Pharmacol. 1976;292(1):73-7. doi: 10.1007/BF00506492.

Jejunal loops of anaesthetized rats were filled with buffered isotonic solutions of tritiated water (HTO), urea, antipyrine and salicylic acid at pH 6-8. The venous outflow and the appearence rate of the substances in the intestinal venous blood were determined. Blood pressure was kept constant by adjustable supply of blood from donor rats throughout the experiment. 2. The absorption of urea, antipyrine and salicylic acid was, in concentrations from 0.001 to 1.0 mg/ml found to be directly proportional to the intraluminal concentration. 3. Theophylline and caffeine (2 mg/ml), when injected into the lumen, increased the blood flow to 188% and 166% of controls. 4. The theophylline induced increase in blood flow caused an enhancement in the absorption of antipyrine to 153%, HTO and urea to 135% and salicylic acid 123% of controls. 5. Caffeine influenced the absorption of HTO and salicylic acid similar to theophylline.

将麻醉大鼠的空肠肠袢用pH值为6 - 8的含氚水（HTO）、尿素、安替比林和水杨酸的缓冲等渗溶液充盈。测定肠静脉血中这些物质的静脉流出量和出现率。在整个实验过程中，通过来自供体大鼠的可调节供血使血压保持恒定。2. 发现浓度在0.001至1.0毫克/毫升范围内的尿素、安替比林和水杨酸的吸收与管腔内浓度成正比。3. 当将茶碱和咖啡因（2毫克/毫升）注入肠腔时，血流量增加至对照的188%和166%。4. 茶碱引起的血流量增加使安替比林的吸收增强至对照的153%，HTO和尿素的吸收增强至对照的135%，水杨酸的吸收增强至对照的123%。5. 咖啡因对HTO和水杨酸吸收的影响与茶碱相似。

Beubler E, Lembeck F

Naunyn Schmiedebergs Arch Pharmacol. 1976;292(1):73-7. doi: 10.1007/BF00506492.

Jejunal loops of anaesthetized rats were filled with buffered isotonic solutions of tritiated water (HTO), urea, antipyrine and salicylic acid at pH 6-8. The venous outflow and the appearence rate of the substances in the intestinal venous blood were determined. Blood pressure was kept constant by adjustable supply of blood from donor rats throughout the experiment. 2. The absorption of urea, antipyrine and salicylic acid was, in concentrations from 0.001 to 1.0 mg/ml found to be directly proportional to the intraluminal concentration. 3. Theophylline and caffeine (2 mg/ml), when injected into the lumen, increased the blood flow to 188% and 166% of controls. 4. The theophylline induced increase in blood flow caused an enhancement in the absorption of antipyrine to 153%, HTO and urea to 135% and salicylic acid 123% of controls. 5. Caffeine influenced the absorption of HTO and salicylic acid similar to theophylline.

将麻醉大鼠的空肠肠袢用pH值为6 - 8的含氚水（HTO）、尿素、安替比林和水杨酸的缓冲等渗溶液充盈。测定肠静脉血中这些物质的静脉流出量和出现率。在整个实验过程中，通过来自供体大鼠的可调节供血使血压保持恒定。2. 发现浓度在0.001至1.0毫克/毫升范围内的尿素、安替比林和水杨酸的吸收与管腔内浓度成正比。3. 当将茶碱和咖啡因（2毫克/毫升）注入肠腔时，血流量增加至对照的188%和166%。4. 茶碱引起的血流量增加使安替比林的吸收增强至对照的153%，HTO和尿素的吸收增强至对照的135%，水杨酸的吸收增强至对照的123%。5. 咖啡因对HTO和水杨酸吸收的影响与茶碱相似。