Namer I J, Steibel J, Poulet P, Mauss Y, Armspach J P, Eclancher B, Chambron J
Institut de Physique Biologique, Faculté de Médecine, Strasbourg, France.
Neuroimage. 1994 Nov;1(4):308-12. doi: 10.1006/nimg.1994.1015.
Magnetic resonance imaging (MRI) has been performed to determine the efficacy of hyperbaric oxygen treatment (HBO) on experimental allergic encephalomyelitis (EAE) in Lewis rats. The animals were exposed for 2 x 3 h in a 24-h period at 2 ATA pure O2. Three HBO treatment protocols were used: a 10-day preventive treatment (beginning on the 1st day postimmunization), a 3-day preventive treatment (beginning on the 1st day postimmunization), and a 10-day symptomatic treatment (beginning on the 11th day postimmunization). Based on clinical and MRI observations, this study demonstrates: (i) that HBO treatment does not reduce the blood-brain barrier (BBB) disturbance and cerebral edema in EAE, (ii) that in an opposite way, it provokes reversible BBB breakdown, and (iii) that preventive HBO treatments results in modification of the course of EAE, possibly by immunosuppression effect during the initial sensitization step.
已进行磁共振成像（MRI）以确定高压氧治疗（HBO）对Lewis大鼠实验性变应性脑脊髓炎（EAE）的疗效。在2个绝对大气压（ATA）的纯氧环境中，动物在24小时内接受2×3小时的暴露。使用了三种HBO治疗方案：10天预防性治疗（免疫接种后第1天开始）、3天预防性治疗（免疫接种后第1天开始）和10天症状性治疗（免疫接种后第11天开始）。基于临床和MRI观察，本研究表明：（i）HBO治疗不会减轻EAE中的血脑屏障（BBB）紊乱和脑水肿，（ii）相反，它会引发可逆的BBB破坏，（iii）预防性HBO治疗可能通过在初始致敏步骤中的免疫抑制作用导致EAE病程改变。
