Spiro I J, Gebhardt M C, Jennings L C, Mankin H J, Harmon D C, Suit H D
Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA.
Semin Oncol. 1997 Oct;24(5):540-6.
During the past decade, local control of primary sarcomas of the extremities by radiation and conservative surgery has supplanted more radical compartmental resections or amputations. Reviews of others and our published data show that the probability of achieving local control is highly dependent on achieving negative surgical margins. Other factors, such as pathological grade and size, histopathology, and concomitant chemotherapy may also affect local control, to a much lesser extent, although these are strongly correlated with the likelihood of distant metastatic disease. Appreciation of the importance of these different prognostic factors has been fundamental to the development of the current rationale for sarcoma management.
在过去十年中，通过放疗和保守手术对肢体原发性肉瘤进行局部控制，已取代了更为激进的间隔切除术或截肢术。其他研究及我们已发表的数据回顾表明，实现局部控制的可能性高度依赖于获得阴性手术切缘。其他因素，如病理分级和大小、组织病理学以及辅助化疗，在较小程度上也可能影响局部控制，尽管这些因素与远处转移疾病的可能性密切相关。认识到这些不同预后因素的重要性，对于当前肉瘤治疗理论基础的发展至关重要。
