Friston K J, Buechel C, Fink G R, Morris J, Rolls E, Dolan R J
Wellcome Department of Cognitive Neurology, London, United Kingdom.
Neuroimage. 1997 Oct;6(3):218-29. doi: 10.1006/nimg.1997.0291.
In this paper we introduce the idea of explaining responses, in one cortical area, in terms of an interaction between the influence of another area and some experimental (sensory or task-related) parameter. We refer to these effects as psychophysiological interactions and relate them to interactions based solely on experimental factors (i.e., psychological interactions), in factorial designs, and interactions among neurophysiological measurements (i.e., physiological interactions). We have framed psychophysiological interactions in terms of functional integration by noting that the degree to which the activity in one area can be predicted, on the basis of activity in another, corresponds to the contribution of the second to the first, where this contribution can be related to effective connectivity. A psychophysiological interaction means that the contribution of one area to another changes significantly with the experimental or psychological context. Alternatively these interactions can be thought of as a contribution-dependent change in regional responses to an experimental or psychological factor. In other words the contribution can be thought of as modulating the responses elicited by a particular stimulus or psychological process. The potential importance of this approach lies in (i) conferring a degree of functional specificity on this aspect of effective connectivity and (ii) providing a model of modulation, where the contribution from a distal area can be considered to modulate responses to the psychological or stimulus-specific factor defining the interaction. Although distinct in neurobiological terms, these are equivalent perspectives on the same underlying interaction. We illustrate these points using a functional magnetic resonance imaging study of attention to visual motion and a position emission tomography study of visual priming. We focus on interactions among extrastriate, inferotemporal, and posterior parietal regions during visual processing, under different attentional and perceptual conditions.
在本文中，我们介绍了一种观点，即根据另一个脑区的影响与某些实验（感觉或任务相关）参数之间的相互作用，来解释一个脑区的反应。我们将这些效应称为心理生理相互作用，并将它们与仅基于实验因素的相互作用（即心理相互作用）、析因设计中的相互作用以及神经生理测量之间的相互作用（即生理相互作用）联系起来。我们通过指出以下这点，将心理生理相互作用构建为功能整合的形式：基于另一个脑区的活动来预测一个脑区活动的程度，对应于第二个脑区对第一个脑区的贡献，而这种贡献可以与有效连接性相关。心理生理相互作用意味着一个脑区对另一个脑区的贡献会随着实验或心理背景而显著变化。或者，这些相互作用可以被视为区域对实验或心理因素的反应中依赖于贡献的变化。换句话说，这种贡献可以被认为是对特定刺激或心理过程引发的反应进行调节。这种方法的潜在重要性在于：（i）在有效连接性的这一方面赋予一定程度的功能特异性；（ii）提供一种调节模型，其中来自远端脑区的贡献可以被视为调节对定义相互作用的心理或刺激特异性因素的反应。尽管从神经生物学角度来看有所不同，但这些是对同一潜在相互作用的等效观点。我们通过一项关于视觉运动注意力的功能磁共振成像研究和一项关于视觉启动的正电子发射断层扫描研究来说明这些要点。我们关注在不同注意力和感知条件下，视觉处理过程中纹外、颞下和顶叶后部区域之间的相互作用。
