Johannesson M, Nordqvist A C, Bogdanovic N, Hjelte L, Schalling M
Stockholm CF-center, Department of Paediatrics, Huddinge Hospital.
Biochem Biophys Res Commun. 1997 Oct 20;239(2):606-11. doi: 10.1006/bbrc.1997.7519.
Multidrug resistance (MDR1b) and cystic fibrosis transmembrane conductance regulator (CFTR) proteins are members of the "ATP-binding cassette" superfamily of transporters. They are associated with chloride channel activities and ATP secretion and have complementary patterns of expression in several organs. In the rat uterus, CFTR expression is replaced by MDR1b expression during pregnancy. We have studied whether expression of MDR1b and CFTR also vary in the lung during pregnancy. No variations in MDR1b or CFTR mRNA levels during pregnancy were detected. However, there was an unusual degree of variation in MDR1b mRNA expression in lung parenchyma between animals in both the control group and the pregnant group. If present among humans, polymorphic expression of MDR1 in lung parenchyma may explain part of the differences in lung symptomatology observed in the CF patients carrying the same mutation.
多药耐药蛋白（MDR1b）和囊性纤维化跨膜传导调节因子（CFTR）蛋白是转运体“ATP结合盒”超家族的成员。它们与氯离子通道活性和ATP分泌相关，并且在多个器官中具有互补的表达模式。在大鼠子宫中，怀孕期间CFTR的表达被MDR1b的表达所取代。我们研究了怀孕期间肺中MDR1b和CFTR的表达是否也会发生变化。未检测到怀孕期间MDR1b或CFTR mRNA水平的变化。然而，对照组和怀孕组动物的肺实质中MDR1b mRNA表达存在异常程度的差异。如果在人类中也存在这种情况，肺实质中MDR1的多态性表达可能解释了携带相同突变的囊性纤维化患者中观察到的肺部症状差异的部分原因。
