Kong A, Cox N J
Department of Statistics, University of Chicago, Chicago, IL 60637, US.
Am J Hum Genet. 1997 Nov;61(5):1179-88. doi: 10.1086/301592.
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously suggested approaches to handling less than perfectly informative data can be unacceptably conservative. Situations in which this model may not perform well are discussed, and an alternative model that requires additional computations is suggested.
从基于等位基因共享的连锁分析检验统计量出发，我们提出了一个相关的单参数模型。在一般的缺失数据模式下，该模型允许精确计算似然比和LOD分数，并且通过对现有软件进行简单修改即可实现。最重要的是，可以进行准确的连锁检验。通过一个例子，我们表明一些先前提出的处理信息不完全充分数据的方法可能过于保守而不可接受。我们讨论了该模型可能表现不佳的情况，并提出了一个需要额外计算的替代模型。
