Kim-Motoyama H, Yamaguchi T, Katakura T, Miura M, Ohashi Y, Yazaki Y, Kadawaki T
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Biochem Biophys Res Commun. 1997 Oct 9;239(1):340-4. doi: 10.1006/bbrc.1997.7329.
To examine the relationship between leptin levels and visceral obesity or plasma insulin levels, we studied serum leptin levels, fat distribution assessed by CT scan, and plasma insulin levels during 75 g oral glucose load in 100 Japanese men. Regression analysis adjusted by age and body mass index (BMI) showed leptin levels to be associated with visceral fat area(V)(p = 0.003), subcutaneous fat area(S)(p < 0.0001), and V + S(p < 0.0001), but not with V/S ratio(p = 0.897). By regression analysis adjusted by age, BMI, and V + S, serum leptin levels were still highly and positively correlated with plasma insulin levels during 75 g oral glucose load (p < 0.001), insulin resistance index(p < 0.001), and beta cell function index(p = 0.009) in homeostasis model assessment. These data suggest that hyperinsulinemia, but not visceral obesity, may be regulators of serum leptin levels independent of BMI.
为研究瘦素水平与内脏性肥胖或血浆胰岛素水平之间的关系，我们对100名日本男性进行了研究，检测了他们在口服75克葡萄糖负荷期间的血清瘦素水平、通过CT扫描评估的脂肪分布以及血浆胰岛素水平。经年龄和体重指数（BMI）校正的回归分析显示，瘦素水平与内脏脂肪面积（V）（p = 0.003）、皮下脂肪面积（S）（p < 0.0001）以及V + S（p < 0.0001）相关，但与V/S比值无关（p = 0.897）。经年龄、BMI和V + S校正的回归分析表明，在口服75克葡萄糖负荷期间，血清瘦素水平仍与稳态模型评估中的血浆胰岛素水平（p < 0.001）、胰岛素抵抗指数（p < 0.001）以及β细胞功能指数（p = 0.009）呈高度正相关。这些数据表明，高胰岛素血症而非内脏性肥胖可能是独立于BMI的血清瘦素水平调节因子。
